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    cyp-37B1 Cytochrome P450 [ Caenorhabditis elegans ]

    Gene ID: 180093, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-37B1
    Official Full Name
    Cytochrome P450
    Primary source
    WormBase:WBGene00009226
    Locus tag
    CELE_F28G4.1
    See related
    AllianceGenome:WB:WBGene00009226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in defense response to Gram-positive bacterium. Predicted to be located in membrane. Is expressed in intestinal cell. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-37B1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (16278116..16280616)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Polycystin-Associated Channel-Like Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decrease of Staphylococcus aureus Virulence by Helcococcus kunzii in a Caenorhabditis elegans Model. Ngba Essebe C, et al. Front Cell Infect Microbiol, 2017. PMID 28361041, Free PMC Article
    2. The transcriptional response of Caenorhabditis elegans to Ivermectin exposure identifies novel genes involved in the response to reduced food intake. Laing ST, et al. PLoS One, 2012. PMID 22348077, Free PMC Article
    3. Systematic temperature signaling regulates behavior plasticity. Li Y. Protein Cell, 2011 Oct. PMID 22058030, Free PMC Article
    4. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. Irazoqui JE, et al. PLoS Pathog, 2010 Jul 1. PMID 20617181, Free PMC Article
    5. Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans. Kulas J, et al. Arch Biochem Biophys, 2008 Apr 1. PMID 18282462

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome P450
    NP_507109.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16278116..16280616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074708.7 → NP_507109.1  Cytochrome P450 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17851
      Conserved Domains (1) summary
      pfam00067
      Location:41 → 475
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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