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    pde-6 Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-6 [ Caenorhabditis elegans ]

    Gene ID: 190808, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pde-6
    Official Full Name
    Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-6
    Primary source
    WormBase:WBGene00022389
    Locus tag
    CELE_Y95B8A.10
    See related
    AllianceGenome:WB:WBGene00022389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of oocyte maturation. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8A (phosphodiesterase 8A) and PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pde-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (872755..882713, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sperm mitochondrial-associated cysteine-rich protein-like Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene DZF domain-containing protein Neighboring gene Bursicon;Bursicon subunit alpha;Secreted protein Neighboring gene FBD domain-containing protein Neighboring gene Guanine nucleotide-binding protein alpha-16 subunit Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca. Castaneda PG, et al. PLoS Genet, 2020 Aug. PMID 32776941, Free PMC Article
    2. C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Liu J, et al. Nat Neurosci, 2010 Jun. PMID 20436480, Free PMC Article
    3. SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans. Kim S, et al. Genetics, 2012 Nov. PMID 22887816, Free PMC Article
    4. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article
    5. ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans. Zhao L, et al. PLoS Biol, 2022 Jun. PMID 35727855, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-6
    NP_001122555.1
    • Partially confirmed by transcript evidence
    NP_001293190.1
    • Confirmed by transcript evidence
    NP_001370828.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      872755..882713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383315.1 → NP_001370828.1  putative 3',5'-cyclic phosphodiesterase pde-6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N2V9
      Conserved Domains (1) summary
      pfam00233
      Location:501 → 737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001306261.3 → NP_001293190.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIW4
      Conserved Domains (1) summary
      pfam00233
      Location:227 → 462
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001129083.4 → NP_001122555.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JYF6
      Conserved Domains (1) summary
      pfam00233
      Location:501 → 681
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N2V9.1

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