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    • Showing Current items.

    F39B2.5 SH2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F39B2.5
    Official Full Name
    SH2 domain-containing protein
    Primary source
    WormBase:WBGene00009556
    Locus tag
    CELE_F39B2.5
    See related
    AllianceGenome:WB:WBGene00009556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable signaling adaptor activity. Predicted to be involved in intracellular signal transduction and negative regulation of signal transduction. Orthologous to human SOCS6 (suppressor of cytokine signaling 6) and SOCS7 (suppressor of cytokine signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F39B2.5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (14775184..14776663, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein Neighboring gene ncRNA Neighboring gene TrmE-type G domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 23 Neighboring gene Enoyl reductase (ER) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing protein
    NP_493574.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14775184..14776663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061173.5 → NP_493574.2  SH2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493574.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45498
      Conserved Domains (2) summary
      smart00253
      Location:126 → 169
      SOCS; suppressors of cytokine signalling
      cd10388
      Location:5 → 106
      SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    Nucleotide Protein
    Heading Accession and Version

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