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    sucl-2 Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sucl-2
    Official Full Name
    Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
    Primary source
    WormBase:WBGene00017759
    Locus tag
    CELE_F23H11.3
    See related
    AllianceGenome:WB:WBGene00017759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (ADP-forming). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sucl-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (900138..901412, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit B Neighboring gene Rho-GAP domain-containing protein Neighboring gene putative cardiolipin synthase (CMP-forming)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of succinate-CoA ligase complex (ADP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
    NP_497288.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      900138..901412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064887.8 → NP_497288.1  Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02642
      Conserved Domains (3) summary
      PTZ00187
      Location:19 → 319
      PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
      pfam02629
      Location:32 → 125
      CoA_binding; CoA binding domain
      cl22543
      Location:178 → 303
      Ligase_CoA; CoA-ligase
    Nucleotide Protein
    Heading Accession and Version

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