frm-2 FERM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: frm-2
Official Full Name: FERM domain-containing protein
Primary source: WormBase:WBGene00001489
Locus tag: CELE_T04C9.6
See related: AllianceGenome:WB:WBGene00001489
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in adherens junction. Predicted to be active in cytoskeleton. Is expressed in epithelial cell; intestine; and nervous system. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B) and EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See frm-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (5976781..5982126, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FRM-2 is a homolog of EPBL15/moe/Yurt that promotes epithelial integrity
Title: Morphogenesis of neurons and glia within an epithelium.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T04C9.6 (e-PCR)
- UniSTS:310652

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: FERM domain-containing protein

NP_001040870.1

Confirmed by transcript evidence

NP_001379896.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5976781..5982126 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392115.1 → NP_001379896.1 FERM domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9GP93

Conserved Domains (3) summary

smart00295
Location:37 → 228

B41; Band 4.1 homologues

cd13186
Location:224 → 320

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:333 → 378

FA; FERM adjacent (FA)
NM_001047405.6 → NP_001040870.1 FERM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040870.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZV9

Conserved Domains (3) summary

smart00295
Location:53 → 244

B41; Band 4.1 homologues

cd13186
Location:240 → 336

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:349 → 393

FA; FERM adjacent (FA)