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    hlh-34 Helix-loop-helix 34 [ Caenorhabditis elegans ]

    Gene ID: 179860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlh-34
    Official Full Name
    Helix-loop-helix 34
    Primary source
    WormBase:WBGene00011327
    Locus tag
    CELE_T01D3.2
    See related
    AllianceGenome:WB:WBGene00011327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including nematode pharyngeal pumping; neuron fate specification; and serotonin receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including ABalapaaaa; ABalapaaap; ABalappapa; ABalappapp; and head neurons. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung non-small cell carcinoma; obesity; polycythemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including SIM1 (SIM bHLH transcription factor 1); SIM2 (SIM bHLH transcription factor 2); and HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hlh-34 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (13705967..13707395, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene TIL domain-containing protein;Thyroglobulin type-1 domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Zinc transporter ZIP9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The bHLH-PAS gene hlh-34 is expressed in the AVH, not AVJ interneurons. Cook SJ, et al. MicroPubl Biol, 2021. PMID 34604715, Free PMC Article
    2. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cunningham KA, et al. Cell Metab, 2012 Jul 3. PMID 22768843, Free PMC Article
    3. The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons. Berghoff EG, et al. Elife, 2021 Jun 24. PMID 34165428, Free PMC Article
    4. ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System. Christensen EL, et al. G3 (Bethesda), 2020 Jun 1. PMID 32273286, Free PMC Article
    5. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Lemieux GA, et al. Cell, 2015 Jan 15. PMID 25594177, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in serotonin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Helix-loop-helix 34
    NP_506391.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13705967..13707395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073990.5 → NP_506391.2  Helix-loop-helix 34 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506391.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90953, Q963J3
      Conserved Domains (2) summary
      cd00083
      Location:6 → 67
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:93 → 145
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90953.3

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