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    vars-1 valine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 179184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vars-1
    Official Full Name
    valine--tRNA ligase
    Primary source
    WormBase:WBGene00006935
    Locus tag
    CELE_ZC513.4
    See related
    AllianceGenome:WB:WBGene00006935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vars-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (8031411..8035025)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Glycine N-acyltransferase-like protein Neighboring gene CCCH-type zinc finger protein oma-2 Neighboring gene DUF19 domain-containing protein Neighboring gene Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Maeda I, et al. Curr Biol, 2001 Feb 6. PMID 11231151
    2. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Kamath RS, et al. Nature, 2003 Jan 16. PMID 12529635
    3. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    valine--tRNA ligase
    NP_505070.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8031411..8035025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072669.6 → NP_505070.3  valine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505070.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23360
      Conserved Domains (4) summary
      cd07962
      Location:656 → 782
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      PTZ00419
      Location:54 → 971
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      pfam13603
      Location:242 → 375
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
      cl00015
      Location:59 → 648
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version

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