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    acc-2 Acetylcholine-gated chloride channel subunit acc-2 [ Caenorhabditis elegans ]

    Gene ID: 183758, updated on 9-Dec-2024

    Summary

    Official Symbol
    acc-2
    Official Full Name
    Acetylcholine-gated chloride channel subunit acc-2
    Primary source
    WormBase:WBGene00008280
    Locus tag
    CELE_C53D6.3
    See related
    AllianceGenome:WB:WBGene00008280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See acc-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (9016777..9019186)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Thioredoxin domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Acetylcholine-gated chloride channel subunit acc-2
    NP_501567.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9016777..9019186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069166.3NP_501567.1  Acetylcholine-gated chloride channel subunit acc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18812
      Conserved Domains (2) summary
      pfam02931
      Location:51258
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:267347
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region