R04B3.2 Glycosylasparaginase beta chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: R04B3.2
Official Full Name: Glycosylasparaginase beta chain
Primary source: WormBase:WBGene00019867
Locus tag: CELE_R04B3.2
See related: AllianceGenome:WB:WBGene00019867
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be involved in protein deglycosylation. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See R04B3.2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (2471540..2473718, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R04B3.2 (e-PCR)
- UniSTS:314736

R04B3.3 (e-PCR)
- UniSTS:312714

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Glycosylasparaginase beta chain

NP_508448.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2471540..2473718 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076047.5 → NP_508448.1 Glycosylasparaginase beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508448.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21697

Conserved Domains (1) summary

cd04513
Location:25 → 333

Glycosylasparaginase; Glycosylasparaginase and similar proteins