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    elo-1 Long chain fatty acid elongase 1 [ Caenorhabditis elegans ]

    Gene ID: 177787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elo-1
    Official Full Name
    Long chain fatty acid elongase 1
    Primary source
    WormBase:WBGene00001239
    Locus tag
    CELE_F56H11.4
    See related
    AllianceGenome:WB:WBGene00001239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid elongase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including body wall musculature; enteric muscle; intestine; pharynx; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elo-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (9526366..9528336)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene DUF202 domain-containing protein;Secreted protein;Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Beaudoin F, et al. Proc Natl Acad Sci U S A, 2000 Jun 6. PMID 10829069, Free PMC Article
    2. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Kniazeva M, et al. Genetics, 2003 Jan. PMID 12586704, Free PMC Article
    3. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Beaudoin F, et al. J Biol Chem, 2002 Mar 29. PMID 11792704
    4. Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans. Watts JL, et al. Proc Natl Acad Sci U S A, 2002 Apr 30. PMID 11972048, Free PMC Article
    5. Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Δ6 Desaturase (fat-3) and Generates New ω-3 Endocannabinoids. Guha S, et al. Cells, 2020 Sep 19. PMID 32961767, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Long chain fatty acid elongase 1
    NP_001263767.1
    • Partially confirmed by transcript evidence
    NP_501689.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9526366..9528336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069288.9 → NP_501689.1  Long chain fatty acid elongase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501689.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEE5, K8ES54
      Conserved Domains (1) summary
      pfam01151
      Location:39 → 278
      ELO; GNS1/SUR4 family

    2. NM_001276838.3 → NP_001263767.1  Long chain fatty acid elongase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ES54
      Conserved Domains (1) summary
      pfam01151
      Location:1 → 224
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEE5.1

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