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    gst-28 Glutathione S-Transferase [ Caenorhabditis elegans ]

    Gene ID: 190224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gst-28
    Official Full Name
    Glutathione S-Transferase
    Primary source
    WormBase:WBGene00001776
    Locus tag
    CELE_Y53F4B.31
    See related
    AllianceGenome:WB:WBGene00001776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gst-28 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (15166194..15167406, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glutathione S-Transferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glutathione S-Transferase Neighboring gene Glutathione S-Transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A proteomics approach to quantify protein levels following RNA interference: case study with glutathione transferase superfamily from the model metazoan Caenorhabditis elegans. Lacourse EJ, et al. J Proteome Res, 2008 Aug. PMID 18582093
    2. Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan. Oh M, et al. Sci Rep, 2022 May 3. PMID 35504961, Free PMC Article
    3. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutathione S-Transferase
    NP_497117.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      15166194..15167406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064716.6 → NP_497117.1  Glutathione S-Transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAB2
      Conserved Domains (3) summary
      PTZ00057
      Location:6 → 209
      PTZ00057; glutathione s-transferase; Provisional
      cd03192
      Location:85 → 191
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:4 → 74
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
    Nucleotide Protein
    Heading Accession and Version

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