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    pgp-2 P-GlycoProtein related [ Caenorhabditis elegans ]

    Gene ID: 172262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgp-2
    Official Full Name
    P-GlycoProtein related
    Primary source
    WormBase:WBGene00003996
    Locus tag
    CELE_C34G6.4
    See related
    AllianceGenome:WB:WBGene00003996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in gut granule assembly and lipid storage. Located in gut granule membrane. Is expressed in intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pgp-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (5886613..5895973)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene ShKT domain-containing protein Neighboring gene Signal transducing adapter molecule 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ABC transporter PGP-2 from Caenorhabditis elegans is expressed in the sensory neuron pair AWA and contributes to lysosome formation and lipid storage within the intestine. Nunes F, et al. Biochem Biophys Res Commun, 2005 Dec 16. PMID 16243293
    2. The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans. Chun H, et al. J Biol Chem, 2017 Jan 6. PMID 27881675, Free PMC Article
    3. Lysosome-related organelles promote stress and immune responses in C. elegans. Hajdú G, et al. Commun Biol, 2023 Sep 13. PMID 37704756, Free PMC Article
    4. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Lincke CR, et al. J Mol Biol, 1992 Nov 20. PMID 1360540
    5. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. Broeks A, et al. EMBO J, 1995 May 1. PMID 7743993, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results provide an explanation for the loss of Nile Red-stained fat in pgp-2(-) animals as well as insight into the specialized function of this lysosome-related organelle.
      Title: Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in gut granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in gut granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P-GlycoProtein related
    NP_001300410.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence
    NP_001300411.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence
    NP_001300412.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence
    NP_491707.2
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5886613..5895973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059306.7 → NP_491707.2  P-GlycoProtein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491707.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDF9
      Conserved Domains (3) summary
      cd03249
      Location:399 → 632
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:56 → 1262
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:61 → 349
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001313481.3 → NP_001300410.1  P-GlycoProtein related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQN5
      Conserved Domains (3) summary
      cd03249
      Location:399 → 632
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:56 → 1286
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:61 → 349
      ABC_membrane; ABC transporter transmembrane region

    3. NM_001313483.4 → NP_001300412.1  P-GlycoProtein related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWK1
      Conserved Domains (3) summary
      cd03249
      Location:392 → 625
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:49 → 1255
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:54 → 342
      ABC_membrane; ABC transporter transmembrane region

    4. NM_001313482.3 → NP_001300411.1  P-GlycoProtein related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU66
      Conserved Domains (3) summary
      cd03249
      Location:392 → 625
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:49 → 1279
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:54 → 342
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
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