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    tbc-19 TBC1 domain family member 2B [ Caenorhabditis elegans ]

    Gene ID: 181511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-19
    Official Full Name
    TBC1 domain family member 2B
    Primary source
    WormBase:WBGene00007849
    Locus tag
    CELE_C31E10.8
    See related
    AllianceGenome:WB:WBGene00007849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-19 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    30
    Sequence:
    Chromosome: X; NC_003284.9 (14003020..14012517, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CCDC93 N-terminal domain-containing protein Neighboring gene CCDC93 N-terminal domain-containing protein Neighboring gene Cytochrome b5 heme-binding domain-containing protein Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene Nematode Specific Peptide family, group A Neighboring gene ncRNA Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 2B
    NP_510336.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14003020..14012517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077935.8 → NP_510336.3  TBC1 domain family member 2B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510336.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEB5
      Conserved Domains (3) summary
      smart00164
      Location:448 → 670
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam00169
      Location:16 → 110
      PH; PH domain
      cl17171
      Location:13 → 112
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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