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    wars-1 tryptophan--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 180231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wars-1
    Official Full Name
    tryptophan--tRNA ligase
    Primary source
    WormBase:WBGene00006945
    Locus tag
    CELE_Y80D3A.1
    See related
    AllianceGenome:WB:WBGene00006945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tryptophan-tRNA ligase activity. Predicted to be involved in tryptophanyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wars-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (18852704..18859221, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-65 Neighboring gene Nuclear Hormone Receptor family Neighboring gene AAA_12 domain-containing protein;DNA2/NAM7 helicase-like C-terminal domain-containing protein;Intron-binding protein aquarius Neighboring gene Homeobox protein ceh-51 Neighboring gene Nuclear Hormone Receptor family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans. Izadi M, et al. Cell Death Discov, 2024 Apr 4. PMID 38575580, Free PMC Article
    2. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Kamath RS, et al. Nature, 2003 Jan 16. PMID 12529635
    3. Proteomic analysis of Caenorhabditis elegans. Jeong PY, et al. Methods Mol Biol, 2009. PMID 19381582
    4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan--tRNA ligase
    NP_507683.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18852704..18859221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075282.6 → NP_507683.2  tryptophan--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507683.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDY2
      Conserved Domains (2) summary
      PLN02486
      Location:34 → 414
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:103 → 416
      trpS; tryptophanyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version

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