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    dgk-1 Diacylglycerol kinase [ Caenorhabditis elegans ]

    Gene ID: 180452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgk-1
    Official Full Name
    Diacylglycerol kinase
    Primary source
    WormBase:WBGene00000958
    Locus tag
    CELE_C09E10.2
    See related
    AllianceGenome:WB:WBGene00000958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATP-dependent diacylglycerol kinase activity and small GTPase binding activity. Involved in several processes, including cellular response to dopamine; cholinergic synaptic transmission; and lipid phosphorylation. Located in several cellular components, including axon; cell body; and perinuclear region of cytoplasm. Is expressed in excretory cell; nervous system; and reproductive system. Orthologous to human DGKQ (diacylglycerol kinase theta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dgk-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    17
    Sequence:
    Chromosome: X; NC_003284.9 (983903..991456, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene AB hydrolase-1 domain-containing protein;Protein abhd-3.2 Neighboring gene G protein-coupled receptor Neighboring gene Uncharacterized protein Neighboring gene ZP domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Domains, amino acid residues, and new isoforms of Caenorhabditis elegans diacylglycerol kinase 1 (DGK-1) important for terminating diacylglycerol signaling in vivo. Jose AM, et al. J Biol Chem, 2005 Jan 28. PMID 15563467, Free PMC Article
    2. Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in C. elegans. McMullan R, et al. Genes Dev, 2006 Jan 1. PMID 16391233, Free PMC Article
    3. A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Miller KG, et al. Genetics, 2000 Dec. PMID 11102364, Free PMC Article
    4. nu444 is a novel allele of pkc-1 in C. elegans. Wang H, et al. MicroPubl Biol, 2017 May 18. PMID 32550344, Free PMC Article
    5. Dysregulation of Neuronal Gαo Signaling by Graphene Oxide in Nematode Caenorhabditis elegans. Liu P, et al. Sci Rep, 2019 Apr 15. PMID 30988375, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Forward genetic screen of Caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep.
      Title: Forward genetic screen of Caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep.
    2. diacylglycerol kinase 1 (DGK-1) is important for terminating diacylglycerol signaling in vivo
      Title: Domains, amino acid residues, and new isoforms of Caenorhabditis elegans diacylglycerol kinase 1 (DGK-1) important for terminating diacylglycerol signaling in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of defecation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to food IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Diacylglycerol kinase
    NP_001367480.1
    • Confirmed by transcript evidence
    NP_001367482.1
    • Confirmed by transcript evidence
    NP_001367483.1
    • Confirmed by transcript evidence
    NP_001367484.1
    • Confirmed by transcript evidence
    NP_001379646.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      983903..991456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392723.1 → NP_001379646.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17860
      Conserved Domains (7) summary
      smart00046
      Location:550 → 675
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd17111
      Location:266 → 353
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      pfam00609
      Location:713 → 869
      DAGK_acc; Diacylglycerol kinase accessory domain
      cd20803
      Location:20 → 74
      C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20804
      Location:79 → 135
      C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20854
      Location:150 → 212
      C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cl28922
      Location:359 → 452
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001380901.2 → NP_001367480.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JNZ1
      Conserved Domains (7) summary
      smart00046
      Location:548 → 673
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd17111
      Location:264 → 351
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      pfam00609
      Location:711 → 867
      DAGK_acc; Diacylglycerol kinase accessory domain
      cd20803
      Location:20 → 74
      C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20804
      Location:79 → 135
      C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20854
      Location:150 → 212
      C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cl28922
      Location:357 → 450
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. NM_001380900.1 → NP_001367482.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58AU6
      Conserved Domains (6) summary
      smart00046
      Location:392 → 517
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0724
      Location:224 → 373
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam00609
      Location:555 → 711
      DAGK_acc; Diacylglycerol kinase accessory domain
      cd20803
      Location:20 → 74
      C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20804
      Location:79 → 135
      C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20854
      Location:150 → 212
      C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

    4. NM_001380902.1 → NP_001367483.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58AU5
      Conserved Domains (6) summary
      smart00046
      Location:394 → 519
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0724
      Location:238 → 375
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam00609
      Location:557 → 713
      DAGK_acc; Diacylglycerol kinase accessory domain
      cd20803
      Location:20 → 74
      C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20804
      Location:79 → 135
      C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20854
      Location:150 → 212
      C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

    5. NM_001380904.1 → NP_001367484.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58AU4
      Conserved Domains (7) summary
      smart00046
      Location:517 → 642
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd17111
      Location:249 → 320
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      pfam00609
      Location:680 → 836
      DAGK_acc; Diacylglycerol kinase accessory domain
      cd20803
      Location:20 → 74
      C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20804
      Location:79 → 135
      C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cd20854
      Location:150 → 212
      C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
      cl28922
      Location:326 → 419
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version

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