math-33 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: math-33
Official Full Name: Ubiquitin carboxyl-terminal hydrolase 7
Primary source: WormBase:WBGene00010406
Locus tag: CELE_H19N07.2
See related: AllianceGenome:WB:WBGene00010406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including anterior/posterior axis specification, embryo; hemidesmosome assembly; and maintenance of centrosome location. Located in cytoplasm and nucleus. Is expressed in several structures, including germ line. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See math-33 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (11113907..11118824)

Chromosome V - NC_003283.11 $Genomic Context describing neighboring genes$

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Deubiquitylase MATH-33 stabilizes DAF-16 protein levels in Insulin/IGF-1 signaling.
Title: The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H19N07.2 (e-PCR)
- UniSTS:317499

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification, embryo	IGI Inferred from Genetic Interaction more info	PubMed
involved_in anterior/posterior axis specification, embryo	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of centrosome location	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of centrosome location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Ubiquitin carboxyl-terminal hydrolase 7

NP_001024012.1

Partially confirmed by transcript evidence

NP_001256294.1

Partially confirmed by transcript evidence

NP_001256295.1

Partially confirmed by transcript evidence

NP_001256296.1

Confirmed by transcript evidence

NP_001256297.1

Confirmed by transcript evidence

NP_001256298.1

Confirmed by transcript evidence

NP_001294682.1

Confirmed by transcript evidence

NP_001294683.1

Partially confirmed by transcript evidence

NP_001294684.1

Confirmed by transcript evidence

NP_001294685.1

Partially confirmed by transcript evidence

NP_001294686.1

Confirmed by transcript evidence

NP_001294687.1

Confirmed by transcript evidence

NP_001294688.1

Partially confirmed by transcript evidence

NP_001294689.1

Partially confirmed by transcript evidence

NP_505825.1

Partially confirmed by transcript evidence

NP_505826.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11113907..11118824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028841.5 → NP_001024012.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024012.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7JKC3

Conserved Domains (5) summary

COG5077
Location:4 → 1133

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1122

USP7_C2; Ubiquitin-specific protease C-terminal
NM_001269367.3 → NP_001256296.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256296.1

Status: REVIEWED

UniProtKB/TrEMBL

G3MU82

Conserved Domains (5) summary

COG5077
Location:4 → 1130

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1119

USP7_C2; Ubiquitin-specific protease C-terminal
NM_001269368.3 → NP_001256297.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256297.1

Status: REVIEWED

UniProtKB/TrEMBL

G3MU79

Conserved Domains (5) summary

COG5077
Location:4 → 1129

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1118

USP7_C2; Ubiquitin-specific protease C-terminal
NM_001307753.4 → NP_001294682.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294682.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NTI7

Conserved Domains (5) summary

COG5077
Location:4 → 1132

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1121

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_001307757.3 → NP_001294686.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294686.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NVB4

Conserved Domains (5) summary

COG5077
Location:4 → 1130

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1119

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_001269366.3 → NP_001256295.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256295.1

Status: REVIEWED

UniProtKB/TrEMBL

G3MU80

Conserved Domains (5) summary

COG5077
Location:4 → 1130

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1119

USP7_C2; Ubiquitin-specific protease C-terminal
NM_073425.8 → NP_505826.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505826.1

Status: REVIEWED

UniProtKB/TrEMBL

O45624

Conserved Domains (5) summary

COG5077
Location:4 → 1128

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1117

USP7_C2; Ubiquitin-specific protease C-terminal
NM_001307755.3 → NP_001294684.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294684.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NTD2

Conserved Domains (5) summary

COG5077
Location:4 → 1131

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1120

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_001269365.3 → NP_001256294.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256294.1

Status: REVIEWED

UniProtKB/TrEMBL

G3MU83

Conserved Domains (5) summary

COG5077
Location:4 → 1132

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1121

USP7_C2; Ubiquitin-specific protease C-terminal
NM_001307758.3 → NP_001294687.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294687.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NTJ2

Conserved Domains (5) summary

COG5077
Location:4 → 1133

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1122

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_001307754.4 → NP_001294683.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294683.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NSD8

Conserved Domains (5) summary

COG5077
Location:4 → 1135

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1124

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_001307760.4 → NP_001294689.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294689.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NTD8

Conserved Domains (5) summary

COG5077
Location:4 → 1136

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1125

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_001269369.3 → NP_001256298.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256298.1

Status: REVIEWED

UniProtKB/TrEMBL

G3MU81

Conserved Domains (5) summary

COG5077
Location:4 → 1127

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1116

USP7_C2; Ubiquitin-specific protease C-terminal
NM_001307756.4 → NP_001294685.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294685.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NV07

Conserved Domains (5) summary

COG5077
Location:4 → 1134

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1123

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
NM_073424.5 → NP_505825.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505825.1

Status: REVIEWED

UniProtKB/TrEMBL

O45623

Conserved Domains (5) summary

COG5077
Location:4 → 1131

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:191 → 504

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:30 → 179

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:633 → 860

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:897 → 1120

USP7_C2; Ubiquitin-specific protease C-terminal
NM_001307759.4 → NP_001294688.1 Ubiquitin carboxyl-terminal hydrolase 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294688.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NSE3

Conserved Domains (5) summary

COG5077
Location:4 → 1133

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:194 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12436
Location:636 → 863

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:900 → 1122

USP7_C2; Ubiquitin-specific protease C-terminal

cl02446
Location:30 → 182

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...