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    npr-4 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npr-4
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00007635
    Locus tag
    CELE_C16D6.2
    See related
    AllianceGenome:WB:WBGene00007635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in regulation of muscle contraction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including PQR; coelomocyte; interneuron; nerve ring; and rectal gland cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npr-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (12536978..12551684, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Suppressor of Constitutive Dauer formation Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Brugia malayi neuropeptide receptor-4 is activated by FMRFamide-like peptides and signals via Gαi. Anderson RC, et al. Mol Biochem Parasitol, 2014 Jun. PMID 25038481
    2. FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length in Caenorhabditis elegans. Bhardwaj A, et al. J Neurosci, 2018 May 16. PMID 29712787, Free PMC Article
    3. Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling. Cohen M, et al. Cell Metab, 2009 Apr. PMID 19356718
    4. Mitochondria-controlled neuropeptide release induces oxidative stress resistance. Ullrich F. Nat Struct Mol Biol, 2021 May. PMID 33972786
    5. FLP-4 neuropeptide and its receptor in a neuronal circuit regulate preference choice through functions of ASH-2 trithorax complex in Caenorhabditis elegans. Yu Y, et al. Sci Rep, 2016 Feb 18. PMID 26887501, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our analysis suggests that the FLP-18/NPR-1/NPR-4 signaling is a pivotal point in the regulation of reversal length under varied genetic and environmental conditions
      Title: FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001294802.1
    • Partially confirmed by transcript evidence
    NP_001294803.1
    • Partially confirmed by transcript evidence
    NP_001300304.1
    • Partially confirmed by transcript evidence
    NP_510101.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12536978..12551684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307874.4 → NP_001294803.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BS36
      Conserved Domains (1) summary
      cd15203
      Location:50 → 346
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_077700.7 → NP_510101.2  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510101.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62062
      Conserved Domains (1) summary
      cd15203
      Location:28 → 324
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001313375.3 → NP_001300304.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYF5
      Conserved Domains (1) summary
      cd15203
      Location:50 → 346
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001307873.3 → NP_001294802.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BTK0
      Conserved Domains (1) summary
      cd15203
      Location:28 → 324
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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