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    nhr-91 Nuclear hormone receptor family member nhr-91 [ Caenorhabditis elegans ]

    Gene ID: 181621, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-91
    Official Full Name
    Nuclear hormone receptor family member nhr-91
    Primary source
    WormBase:WBGene00003681
    Locus tag
    CELE_Y15E3A.1
    See related
    AllianceGenome:WB:WBGene00003681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in anterior ganglion; excretory cell; seam cell; spermatheca; and vulva. Orthologous to human NR6A1 (nuclear receptor subfamily 6 group A member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-91 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (15309375..15314898)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Globin domain-containing protein Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microRNA miR-235 couples blast-cell quiescence to the nutritional state. Kasuga H, et al. Nature, 2013 May 23. PMID 23644454
    2. Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. Ward JD, et al. PLoS Genet, 2013. PMID 24348269, Free PMC Article
    3. ATP-binding cassette protein E is involved in gene transcription and translation in Caenorhabditis elegans. Zhao Z, et al. Biochem Biophys Res Commun, 2004 Oct 8. PMID 15351708
    4. Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans. Tam AS, et al. G3 (Bethesda), 2015 Nov 12. PMID 26564951, Free PMC Article
    5. Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. Robinson-Rechavi M, et al. J Mol Evol, 2005 May. PMID 15983867

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-91
    NP_001024953.1
    • Confirmed by transcript evidence
    NP_001379437.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15309375..15314898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029782.6 → NP_001024953.1  Nuclear hormone receptor family member nhr-91 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024953.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6V7K9, Q9U2R6
      UniProtKB/TrEMBL
      G5EG56
      Conserved Domains (2) summary
      cd06953
      Location:222 → 465
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:92 → 181
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    2. NM_001392897.1 → NP_001379437.1  Nuclear hormone receptor family member nhr-91 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd06953
      Location:58 → 301
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cl02596
      Location:1 → 17
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2R6.2

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