ces-2 Transcription factor ces-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ces-2
Official Full Name: Transcription factor ces-2
Primary source: WormBase:WBGene00000469
Locus tag: CELE_ZK909.4
See related: AllianceGenome:WB:WBGene00000469
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including apoptotic process; positive regulation of programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in excretory duct cell. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human DBP (D-box binding PAR bZIP transcription factor); HLF (HLF transcription factor, PAR bZIP family member); and TEF (TEF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ces-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (14961497..14965361)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, we show that CES-2 mediates its effects in one cell (the excretory duct cell) together with another bZip protein, ATF-2.
Title: The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK909.4 (e-PCR)
- UniSTS:322480

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor ces-2

NP_493610.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14961497..14965361

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061209.6 → NP_493610.1 Transcription factor ces-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493610.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94126

Conserved Domains (1) summary

cd14695
Location:115 → 173

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain