eif-2beta Eukaryotic translation initiation factor 2 subunit 2 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: eif-2beta
Official Full Name: Eukaryotic translation initiation factor 2 subunit 2
Primary source: WormBase:WBGene00010560
Locus tag: CELE_K04G2.1
See related: AllianceGenome:WB:WBGene00010560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Involved in determination of adult lifespan; regulation of growth; and translation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2 complex. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See eif-2beta in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (8026615..8027792, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isolation and characterization of mutations in eif-2Ba encoding the a-subunit of eIF2B support a conserved role for eIF2Balpha in providing a binding site for phosphorylated eIF2a to inhibit the exchange factor eIF2B catalytic activity that is required for translation initiation
Title: Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans.
These analyses further support the critical role of eIF2beta in start codon selection.
Title: Mutations in Caenorhabditis elegans eIF2beta permit translation initiation from non-AUG start codons.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

K04G2.1 (e-PCR)
- UniSTS:307764

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Eukaryotic translation initiation factor 2 subunit 2

NP_492209.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8026615..8027792 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059808.7 → NP_492209.1 Eukaryotic translation initiation factor 2 subunit 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492209.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18855, Q21230

Conserved Domains (1) summary

smart00653
Location:111 → 220

eIF2B_5; domain present in translation initiation factor eIF2B and eIF5