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    prp-40 Pre-mRNA-processing factor 40 homolog B;WW domain-containing protein ZK1098.1 [ Caenorhabditis elegans ]

    Gene ID: 176343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prp-40
    Official Full Name
    Pre-mRNA-processing factor 40 homolog B;WW domain-containing protein ZK1098.1
    Primary source
    WormBase:WBGene00014218
    Locus tag
    CELE_ZK1098.1
    See related
    AllianceGenome:WB:WBGene00014218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including body wall musculature; gonad; intestine; and nervous system. Orthologous to several human genes including PRPF40A (pre-mRNA processing factor 40 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prp-40 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (9522075..9525454)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Clustered mitochondria protein homolog Neighboring gene Small ribosomal subunit protein mS23 Neighboring gene Trafficking protein particle complex subunit 3 homolog Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Conserved Role for Stomatin Domain Genes in Olfactory Behavior. Liang X, et al. eNeuro, 2023 Mar. PMID 36858824, Free PMC Article
    2. Spliceosomal component PRP-40 is a central regulator of microexon splicing. Choudhary B, et al. Cell Rep, 2021 Aug 3. PMID 34348142, Free PMC Article
    3. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Fridolfsson HN, et al. Dev Biol, 2010 Feb 15. PMID 20005871, Free PMC Article
    4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spliceosomal component PRP-40 is a central regulator of microexon splicing.
      Title: Spliceosomal component PRP-40 is a central regulator of microexon splicing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Pre-mRNA-processing factor 40 homolog B;WW domain-containing protein ZK1098.1
    NP_001255005.1
    • Confirmed by transcript evidence
    NP_001255006.1
    • Confirmed by transcript evidence
    NP_001407496.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9522075..9525454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268076.2 → NP_001255005.1  WW domain-containing protein ZK1098.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255005.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G3MTW8, P34600
      Conserved Domains (4) summary
      smart00441
      Location:225 → 282
      FF; Contains two conserved F residues
      smart00456
      Location:129 → 156
      WW; Domain with 2 conserved Trp (W) residues
      pfam00397
      Location:82 → 109
      WW; WW domain
      pfam01846
      Location:580 → 629
      FF; FF domain

    2. NM_001420554.1 → NP_001407496.1  Pre-mRNA-processing factor 40 homolog B [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D8EJE6

    3. NM_001268077.3 → NP_001255006.1  WW domain-containing protein ZK1098.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255006.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34600
      Conserved Domains (2) summary
      smart00441
      Location:52 → 111
      FF; Contains two conserved F residues
      pfam01846
      Location:269 → 318
      FF; FF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34600.2

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