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    pgm-2 PGM_PMM_I domain-containing protein;Phosphoglucomutase-2 [ Caenorhabditis elegans ]

    Gene ID: 176749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgm-2
    Official Full Name
    PGM_PMM_I domain-containing protein;Phosphoglucomutase-2
    Primary source
    WormBase:WBGene00012803
    Locus tag
    CELE_Y43F4B.5
    See related
    AllianceGenome:WB:WBGene00012803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphopentomutase activity. Predicted to be involved in purine ribonucleoside salvage. Located in nucleus. Orthologous to human PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pgm-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (13299378..13302760)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase set-25 Neighboring gene ncRNA Neighboring gene Nucleoporin SEH1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Kinesin-like protein klp-19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopentomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    PGM_PMM_I domain-containing protein;Phosphoglucomutase-2
    NP_001022872.1
    • Confirmed by transcript evidence
    NP_001022873.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13299378..13302760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027701.5 → NP_001022872.1  Phosphoglucomutase-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022872.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45934
      Conserved Domains (2) summary
      cd05799
      Location:47 → 574
      PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...
      PTZ00150
      Location:7 → 595
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    2. NM_001027702.5 → NP_001022873.1  PGM_PMM_I domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86DA0
      Conserved Domains (1) summary
      cl03757
      Location:47 → 323
      phosphohexomutase; The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine ...
    Nucleotide Protein
    Heading Accession and Version

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