gly-2 Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gly-2
Official Full Name: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
Primary source: WormBase:WBGene00001627
Locus tag: CELE_C55B7.2
See related: AllianceGenome:WB:WBGene00001627
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calmodulin binding activity and hexosyltransferase activity. Involved in protein N-linked glycosylation. Located in nucleus. Is expressed in hermaphrodite gonad; neurons; pharyngeal-intestinal valve; pm8; and somatic nervous system. Orthologous to human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) and MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gly-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (6507894..6511619)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C55B7.10 (e-PCR)
- UniSTS:306773

C55B7.2 (e-PCR)
- UniSTS:309426

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein N-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase

NP_491874.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6507894..6511619

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059473.9 → NP_491874.1 Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491874.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q962C0, Q9NDH7

Conserved Domains (1) summary

pfam15024
Location:99 → 654

Glyco_transf_18; Glycosyltransferase family 18