U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mt-Nd5 NADH dehydrogenase 5, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26202, updated on 2-Nov-2024

    Summary

    Official Symbol
    mt-Nd5provided by RGD
    Official Full Name
    NADH dehydrogenase 5, mitochondrialprovided by RGD
    Primary source
    RGD:620560
    See related
    AllianceGenome:RGD:620560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus (strain: BN/SsNHsdMCW)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ND5
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in response to hydrogen peroxide and response to hypoxia. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. Orthologous to human MT-ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See mt-Nd5 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (11736..13565)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (11736..13565)

    Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene tRNA-Ser Neighboring gene tRNA-Leu Neighboring gene NADH dehydrogenase subunit 6 Neighboring gene tRNA-Glu Neighboring gene cytochrome b

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    • Nd5; NADH5

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase subunit 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001665.2 Reference assembly

      Range
      11736..13565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_665639.1 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]

      See identical proteins and their annotated locations for YP_665639.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P11661
      UniProtKB/TrEMBL
      A0A096XKT9, Q06QG6, Q06QK5, Q8SEZ0
      Conserved Domains (1) summary
      MTH00108
      Location:1600
      ND5; NADH dehydrogenase subunit 5; Provisional