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    mt-Nd2 NADH dehydrogenase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26194, updated on 2-Nov-2024

    Summary

    Official Symbol
    mt-Nd2provided by RGD
    Official Full Name
    NADH dehydrogenase 2, mitochondrialprovided by RGD
    Primary source
    RGD:620556
    See related
    AllianceGenome:RGD:620556
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus (strain: BN/SsNHsdMCW)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ND2
    Summary
    Enables ionotropic glutamate receptor binding activity and protein kinase binding activity. Involved in response to hypoxia. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; multiple sclerosis; myocardial infarction; neurodegenerative disease (multiple); and urinary bladder cancer. Orthologous to human MT-ND2 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See mt-Nd2 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (3904..4942)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (3904..4942)

    Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene tRNA-Gln Neighboring gene tRNA-Met Neighboring gene tRNA-Trp Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    • Nd2; NADH2

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase subunit 2
    YP_665630.1
    • TAA stop codon is completed by the addition of 3' A residues to the mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001665.2 Reference assembly

      Range
      3904..4942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_665630.1 NADH dehydrogenase subunit 2 (mitochondrion) [Rattus norvegicus]

      See identical proteins and their annotated locations for YP_665630.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P11662
      UniProtKB/TrEMBL
      D2E6P4, Q8HID0
      Conserved Domains (1) summary
      MTH00105
      Location:1326
      ND2; NADH dehydrogenase subunit 2; Provisional