Alpl alkaline phosphatase, biomineralization associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alplprovided by RGD
Official Full Name: alkaline phosphatase, biomineralization associatedprovided by RGD
Primary source: RGD:2100
See related: EnsemblRapid:ENSRNOG00000013954 AllianceGenome:RGD:2100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Akp2; PHOA; TNAP; TNSALP; AP-TNAP
Summary: Enables alkaline phosphatase activity. Involved in several processes, including cementum mineralization; response to insulin; and response to macrophage colony-stimulating factor. Located in extracellular space. Is active in extracellular membrane-bounded organelle. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 605.2), Lung (RPKM 229.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (155234770..155289785, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149951397..150006424, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (156086496..156141513, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-beta1/Smads and activating P53 signaling pathways.
Title: TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways.
he rats body weight were decreased, the cartilage histological structure were disrupted, the cartilage and serum contents of Al and the serum level of C-telopeptide of type II collagen were all increased, the serum level of type II collagen (Col II) and alkaline phosphatase (ALP), and the mRNA expressions of TGF-beta1, BMP-2, ALP and Col II were all decreased in the AlCl3-treated groups compared with those in control g...
Title: Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats.
Data show that nonylphenol (NP) increased serum alkaline phosphatase, lead to liver damage and can increase the expression of heme oxygenase-1 (HO1) and growth arrest and DNA-damage-inducible 45 beta protein (Gadd45b) genes and may modify the toxic effects on liver through induction of oxidative stress.
Title: Nonylphenol induces liver toxicity and oxidative stress in rat.
TNAP contributes to the hypertrophic effect of phenylephrine, as well as its ability to produce cardiomyocyte calcification. These responses are minimized by CD73-dependent endogenously produced adenosine.
Title: CD73-TNAP crosstalk regulates the hypertrophic response and cardiomyocyte calcification due to α1 adrenoceptor activation.
TNAP histochemistry offers a more straightforward, but also more sensitive, method for investigating retinal strata and their diabetes-induced degeneration.
Title: Stratified organization and disorganization of inner plexiform layer revealed by TNAP activity in healthy and diabetic rat retina.
Rat pups fed IAP had decreased mRNA expression of the inflammatory cytokines TNFalpha, IL-6 and iNOS.
Title: Intestinal alkaline phosphatase is protective to the preterm rat pup intestine.
BMP-2 and ALP gene expression is induced by a BMP-2 gene-fibronectin-apatite composite layer
Title: BMP-2 and ALP gene expression induced by a BMP-2 gene-fibronectin-apatite composite layer.
The expression of ENPP1, TNAP and ANK proteins could be detected in each generation of endplate chondrocytes. With the continuing passage of cells, the level of protein expression declined gradually.
Title: [Expression and significance of ENPP1, TNAP and ANK proteins in the degeneration of endplate chondrocytes in rats].
Data show that alkaline phosphatase (AP) activity in brain vessels and parenchyma in which AP exhibits specific patterns is attributable to TNAP.
Title: Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues.
Forty SNPs in ALPL and 14 SNPs in ENPP1 genetic loci as well as pairwise haplotypes were tested for association with bone strength related traits.
Title: Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:178682 (e-PCR)
- UniSTS:155039

ALPL (e-PCR)
- UniSTS:519079

RH139790 (e-PCR)
- UniSTS:221874

Alpl (e-PCR), detects polymorphism
- UniSTS:526003

RH128328 (e-PCR)
- UniSTS:211636

RH94490 (e-PCR)
- UniSTS:119738

UniSTS:498363 (e-PCR)
- UniSTS:498363

Akp2 (e-PCR), detects polymorphism
- UniSTS:498363

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkaline phosphatase activity	ISO Inferred from Sequence Orthology more info
enables alkaline phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables inorganic diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoamidase activity	ISO Inferred from Sequence Orthology more info
enables phosphoamidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoethanolamine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphatase activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables pyrophosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biomineral tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cementum mineralization	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within developmental process involved in reproduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in futile creatine cycle	ISO Inferred from Sequence Orthology more info
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyridoxal phosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to macrophage colony-stimulating factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin B6	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin D	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alkaline phosphatase, tissue-nonspecific isozyme

Names: Tissue-nonspecific ALP alkaline phosphatase; alkaline phosphatase 2, liver; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; phosphoamidase; phosphocreatine phosphatase; tissue-nonspecific alkaline phosphatase

NP_037191.2

EC 3.1.3.1

EC 3.9.1.1

XP_006239198.1

EC 3.1.3.1

EC 3.9.1.1

XP_063143270.1

EC 3.1.3.1

EC 3.9.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429380.1 → NP_001416309.1 alkaline phosphatase, tissue-nonspecific isozyme precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P08289, P14055, P70707

UniProtKB/TrEMBL

A6ITE7
NM_013059.3 → NP_037191.2 alkaline phosphatase, tissue-nonspecific isozyme precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P08289, P14055, P70707

UniProtKB/TrEMBL

A6ITE7

Related

ENSRNOP00000019004.3, ENSRNOT00000019004.7

Conserved Domains (1) summary

pfam00245
Location:51 → 490

Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

155234770..155289785 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287200.1 → XP_063143270.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1
XM_006239136.5 → XP_006239198.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1

See identical proteins and their annotated locations for XP_006239198.1

UniProtKB/Swiss-Prot

P08289, P14055, P70707

UniProtKB/TrEMBL

A6ITE7

Conserved Domains (1) summary

pfam00245
Location:51 → 490

Alk_phosphatase; Alkaline phosphatase