PUS5 pseudouridine synthase PUS5 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PUS5
Official Full Name: pseudouridine synthase PUS5
Primary source: SGD:S000004155
Locus tag: YLR165C
See related: AllianceGenome:SGD:S000004155; FungiDB:YLR165C; VEuPathDB:YLR165C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pseudouridylate synthase activity. Involved in pseudouridine synthesis and rRNA modification. Located in mitochondrion. Orthologous to human RPUSD3 (RNA pseudouridine synthase D3) and RPUSD4 (RNA pseudouridine synthase D4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 21S rRNA pseudouridine(2819) synthase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables pseudouridylate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in enzyme-directed rRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in pseudouridine synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

NP_013266.1

Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability

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