ADH6 NADP-dependent alcohol dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADH6
Official Full Name: NADP-dependent alcohol dehydrogenase
Primary source: SGD:S000004937
Locus tag: YMR318C
See related: AllianceGenome:SGD:S000004937; FungiDB:YMR318C; VEuPathDB:YMR318C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADHVI
Summary: Enables alcohol dehydrogenase (NADP+) activity; hydroxymethylfurfural reductase (NADH) activity; and hydroxymethylfurfural reductase (NADPH) activity. Involved in alcohol metabolic process and furaldehyde metabolic process. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ADH6 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (911061..912143, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adh6, acting as a selective SNO-CoA reductase, protects acetoacetyl-CoA thiolase from inhibitory S-nitrosylation and thereby affects sterol biosynthesis.
Title: Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-methylbutanal reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables cinnamyl-alcohol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables hydroxymethylfurfural reductase (NADH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydroxymethylfurfural reductase (NADPH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in alcohol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in alcohol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aldehyde metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in furaldehyde metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADP-dependent alcohol dehydrogenase

NP_014051.3

EC 1.1.1.2

NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

911061..912143 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182831.3 → NP_014051.3 TPA: NADP-dependent alcohol dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014051.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0E6, Q04894

UniProtKB/TrEMBL

A6ZN36, B3LMK7, B5VQ85, C7GPU5, C8ZFJ1, G2WL30, N1NYX0

Conserved Domains (1) summary

cd05283
Location:8 → 352

CAD1; Cinnamyl alcohol dehydrogenases (CAD)