U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GGC1 Ggc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851329, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GGC1
    Official Full Name
    Ggc1p
    Primary source
    SGD:S000002357
    Locus tag
    YDL198C
    See related
    AllianceGenome:SGD:S000002357; FungiDB:YDL198C; VEuPathDB:YDL198C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SHM1; YHM1
    Summary
    Enables guanine nucleotide transmembrane transporter activity. Involved in several processes, including guanine nucleotide transport; intracellular iron ion homeostasis; and mitochondrial genome maintenance. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GGC1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (103649..104551, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene methylated-DNA--protein-cysteine methyltransferase Neighboring gene uncharacterized protein Neighboring gene Asf2p Neighboring gene Sec31p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role of YHM1, encoding a mitochondrial carrier protein, in iron distribution of yeast. Lesuisse E, et al. Biochem J, 2004 Mar 1. PMID 14629196, Free PMC Article
    2. Mapping conformational heterogeneity of mitochondrial nucleotide transporter in uninhibited states. Sounier R, et al. Angew Chem Int Ed Engl, 2015 Feb 16. PMID 25605594, Free PMC Article
    3. Identification of the mitochondrial GTP/GDP transporter in Saccharomyces cerevisiae. Vozza A, et al. J Biol Chem, 2004 May 14. PMID 14998997
    4. SHM1: a multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene. Kao LR, et al. Yeast, 1996 Sep 30. PMID 8905928
    5. Co-precipitation of phosphate and iron limits mitochondrial phosphate availability in Saccharomyces cerevisiae lacking the yeast frataxin homologue (YFH1). Seguin A, et al. J Biol Chem, 2011 Feb 25. PMID 21189251, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GGC1, a mitochondrial GTP/GDP carrier, was identified as a new component of the rapamycin/target of rapamycin (TOR) signaling pathway.
      Title: Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanine nucleotide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanine nucleotide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in guanine nucleotide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in guanine nucleotide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ggc1p
    NP_010083.1
    • Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      103649..104551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180258.1 → NP_010083.1  TPA: Ggc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010083.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRF6, P38988
      UniProtKB/TrEMBL
      A6ZXD5, B3LH79, C7GV59, C8Z6A6, G2WBW9, N1P8H5
      Conserved Domains (1) summary
      pfam00153
      Location:206 → 286
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38988.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools