MCD4 mannose-ethanolamine phosphotransferase MCD4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MCD4
Official Full Name: mannose-ethanolamine phosphotransferase MCD4
Primary source: SGD:S000001648
Locus tag: YKL165C
See related: AllianceGenome:SGD:S000001648; FungiDB:YKL165C; VEuPathDB:YKL165C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FSR2; SSU21; ZRG16
Summary: Enables mannose-ethanolamine phosphotransferase activity. Involved in ATP transport and GPI anchor biosynthetic process. Located in endoplasmic reticulum; fungal-type cell wall; and fungal-type vacuole. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MCD4 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (137932..140691, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caffeine sensitivity caused by the ssu21 mutation could be due to cytoplasmic accumulation of misfolded proteins destined for degradation.
Title: [Caffeine sensitivity of the yeast Saccharomyces cerevisiae MCD4 mutant is related to alteration of calcium homeostasis and degradation of misfolded proteins].

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables mannose-ethanolamine phosphotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannose-ethanolamine phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables mannose-ethanolamine phosphotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in organophosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannose-ethanolamine phosphotransferase MCD4

NP_012756.1

Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

137932..140691 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179731.1 → NP_012756.1 TPA: mannose-ethanolamine phosphotransferase MCD4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012756.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX34, P36051

UniProtKB/TrEMBL

A6ZZF9, B3LQT9, C8ZC09, N1P8A4

Conserved Domains (2) summary

cd16020
Location:46 → 353

GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N

pfam04987
Location:443 → 874

PigN; Phosphatidylinositolglycan class N (PIG-N)