RAS2 Ras family GTPase RAS2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RAS2
Official Full Name: Ras family GTPase RAS2
Primary source: SGD:S000005042
Locus tag: YNL098C
See related: AllianceGenome:SGD:S000005042; FungiDB:YNL098C; VEuPathDB:YNL098C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CTN5; CYR3; GLC5; TSL7
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including cytoplasm to vacuole targeting by the Cvt pathway; positive regulation of transcription by galactose; and protein localization to bud neck. Located in several cellular components, including endoplasmic reticulum membrane; mitochondrion; and nucleus. Used to study colorectal cancer. Human ortholog(s) of this gene implicated in Noonan syndrome 12 and colorectal cancer. Orthologous to human RRAS (RAS related) and RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RAS2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (439602..440570, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function.
Title: Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function.
Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway-dependent manner in budding yeast.
Title: Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway-dependent manner in budding yeast.
Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation.
Title: Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation.
Fructose-1,6-bisphosphate is a potent activator of Ras2 in permeabilized yeast cells, likely acting through Cdc25.
Title: Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras.
Dominant negative Ras2 mutants survive lethal stressors following mild heat shock
Title: Ras mutants enhance the ability of cells to anticipate future lethal stressors.
These data show that deletion of any of Ras2, Tor1, or Sch9 proteins mimics calorie restriction and is sufficient to increase cell protection from oxydative stress.
Title: Protection against cisplatin in calorie-restricted Saccharomyces cerevisiae is mediated by the nutrient-sensor proteins Ras2, Tor1, or Sch9 through its target glutathione.
Rck1 promotes pseudohyphal growth by activating Ras2 and Kss1 in S. cerevisiae.
Title: Rck1 up-regulates pseudohyphal growth by activating the Ras2 and MAP kinase pathways independently in Saccharomyces cerevisiae.
Active Ras accumulates in internal membranes and mitochondria, both when cells are growing on glucose medium or are starved.
Title: Live-cell imaging of endogenous Ras-GTP shows predominant Ras activation at the plasma membrane and in the nucleus in Saccharomyces cerevisiae.
The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate.
Title: The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate.
RAS2 regulates spore formation via Ras/cyclic AMP/protein kinase A pathway.
Title: Acetate regulation of spore formation is under the control of the Ras/cyclic AMP/protein kinase A pathway and carbon dioxide in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ascospore formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by galactose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to bud neck	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytoplasmic mRNA processing body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ras family GTPase RAS2

NP_014301.1

EC 3.6.5.2

GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

439602..440570 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182936.1 → NP_014301.1 TPA: Ras family GTPase RAS2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014301.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W181, P01120, Q45U01

UniProtKB/TrEMBL

A6ZRY2, B3LNV7, B5VQU4, C7GR80, C8ZGD1, G2WM06, N1NXG7

Conserved Domains (1) summary

smart00010
Location:9 → 172

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily