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    GCY1 glycerol 2-dehydrogenase (NADP(+)) GCY1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCY1
    Official Full Name
    glycerol 2-dehydrogenase (NADP(+)) GCY1
    Primary source
    SGD:S000005646
    Locus tag
    YOR120W
    See related
    AllianceGenome:SGD:S000005646; FungiDB:YOR120W; VEuPathDB:YOR120W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aldose reductase (NADPH) activity; glycerol dehydrogenase [NAD(P)+] activity; and mRNA binding activity. Involved in cellular response to oxidative stress; glycerol to glycerone phosphate metabolic process; and pentose catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; congenital bile acid synthesis defect 2; diabetic neuropathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B) and AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GCY1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (551114..552052)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rtc5p Neighboring gene protein kinase RIO1 Neighboring gene profilin Neighboring gene Leo1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional control by galactose of a yeast gene encoding a protein homologous to mammalian aldo/keto reductases. Magdolen V, et al. Gene, 1990 May 31. PMID 2199324
    2. A nuclear yeast gene (GCY) encodes a polypeptide with high homology to a vertebrate eye lens protein. Oechsner U, et al. FEBS Lett, 1988 Sep 26. PMID 2901985
    3. The general regulatory factor Reb1p controls basal, but not Gal4p-mediated, transcription of the GCY1 gene in yeast. Angermayr M, et al. Mol Gen Genet, 1997 Nov. PMID 9435793
    4. Crystallization and aldo-keto reductase activity of Gcy1p from Saccharomyces cerevisiae. Hur E, et al. Acta Crystallogr D Biol Crystallogr, 2000 Jun. PMID 10818358
    5. The crystal structure of the GCY1 protein from S. cerevisiae suggests a divergent aldo-keto reductase catalytic mechanism. Hur E, et al. Chem Biol Interact, 2001 Jan 30. PMID 11306072

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol 2-dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol dehydrogenase [NAD(P)+] activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-xylose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arabinose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arabinose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol to glycerone phosphate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycerol to glycerone phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glycerol 2-dehydrogenase (NADP(+)) GCY1
    NP_014763.1
    • Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      551114..552052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183539.1 → NP_014763.1  TPA: glycerol 2-dehydrogenase (NADP(+)) GCY1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014763.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2H9, P14065
      UniProtKB/TrEMBL
      A6ZNW8, B3LJG3, B5VS12, N1NYF5
      Conserved Domains (1) summary
      cd19117
      Location:7 → 296
      AKR_AKR3A1-2; AKR3A family of aldo-keto reductase (AKR)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14065.1

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