TRIM69 tripartite motif containing 69 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM69provided by HGNC
Official Full Name: tripartite motif containing 69provided by HGNC
Primary source: HGNC:HGNC:17857
See related: Ensembl:ENSG00000185880 MIM:616017; AllianceGenome:HGNC:17857
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Trif; HSD34; RNF36; HSD-34
Summary: This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 19.8) and brain (RPKM 1.8) See more
Orthologs: mouse all
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Genomic context

Location:: 15q21.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (44736528..44767827)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (42544526..42575817)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (45028726..45060025)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin-proteasome-mediated degradation of PRKCD.
Title: TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD.
The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.
Title: The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.
HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.
Title: HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.
Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor.
Title: Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor.
Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.
Title: Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.
we show that TRIM69 is an antiviral defense that can potently and specifically block VSIV infection.
Title: TRIM69 Inhibits Vesicular Stomatitis Indiana Virus.
our results suggested that TRIM69 and p53 are closely involved in cataract formation. TRIM69 inhibited UVB-induced cell apoptosis and ROS production in HLECs by inducing p53 ubiquitination.
Title: TRIM69 inhibits cataractogenesis by negatively regulating p53.
TRIM69 restricts dengue virus replication by specifically ubiquitinating viral nonstructural protein NS3.
Title: Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3.
hTRIM69 is a novel E3 ubiquitin ligase identified from human testis and may function to ubiquitinate its particular substrates during spermatogenesis.
Title: Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation.
Observational study of gene-disease association. (HuGE Navigator)
Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH15707 (e-PCR)
- UniSTS:53585

RH94033 (e-PCR)
- UniSTS:92290

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to centrosome	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM69

Names: RFP-like domain-containing protein trimless; RING-type E3 ubiquitin transferase TRIM69; ring finger protein 36

NP_001288073.1

EC 2.3.2.27

NP_001288074.1

EC 2.3.2.27

NP_001288075.1

EC 2.3.2.27

NP_542783.2

EC 2.3.2.27

NP_892030.3

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033935.1 RefSeqGene

Range

5167..36466

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001301144.2 → NP_001288073.1 E3 ubiquitin-protein ligase TRIM69 isoform c

See identical proteins and their annotated locations for NP_001288073.1

Status: REVIEWED

Description

Transcript Variant: This variant (c) lacks an alternate exon and uses an alternate splice site, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant a. The encoded isoform (c, also known as TRIMLESS alpha) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC122108, AF302088, BI827618, DB524904

Consensus CDS

CCDS73719.1

UniProtKB/Swiss-Prot

Q86WT6

Related

ENSP00000453549.1, ENST00000560442.5

Conserved Domains (1) summary

cd15818
Location:107 → 293

SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
NM_001301145.2 → NP_001288074.1 E3 ubiquitin-protein ligase TRIM69 isoform d

See identical proteins and their annotated locations for NP_001288074.1

Status: REVIEWED

Description

Transcript Variant: This variant (d) lacks an alternate exon and uses two alternate splice sites, and it thus differs in its 5' UTR, initiates translation at a downstream in-frame start codon, and lacks an in-frame segment in the central coding region, compared to variant a. The encoded isoform (d, also known as TRIMLESS beta) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC122108, AF302089, BI827618, DB524904

Consensus CDS

CCDS76746.1

UniProtKB/Swiss-Prot

Q86WT6

Related

ENSP00000453332.1, ENST00000558329.5

Conserved Domains (1) summary

cd15818
Location:90 → 276

SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
NM_001301146.2 → NP_001288075.1 E3 ubiquitin-protein ligase TRIM69 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (e) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant a, resulting in an isoform (e) that is shorter than isoform a.

Source sequence(s)

AC122108, AF302088, BI465168, BI827618, DB524904

Consensus CDS

CCDS76745.1

UniProtKB/TrEMBL

H0YL66

Related

ENSP00000453077.1, ENST00000561043.5

Conserved Domains (1) summary

cd15818
Location:74 → 260

SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
NM_080745.5 → NP_542783.2 E3 ubiquitin-protein ligase TRIM69 isoform b

See identical proteins and their annotated locations for NP_542783.2

Status: REVIEWED

Description

Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AC122108, BC033314, BI827618, DB524904

Consensus CDS

CCDS10114.1

UniProtKB/Swiss-Prot

Q86WT6

Related

ENSP00000342922.4, ENST00000338264.8

Conserved Domains (1) summary

cd15818
Location:152 → 338

SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
NM_182985.5 → NP_892030.3 E3 ubiquitin-protein ligase TRIM69 isoform a

See identical proteins and their annotated locations for NP_892030.3

Status: REVIEWED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC122108, AF302088, AY305385, BI827618, DB524904

Consensus CDS

CCDS32220.1

UniProtKB/Swiss-Prot

A8MX03, Q309B0, Q4G1A5, Q6W897, Q86WT6, Q8IYY3, Q8WY16, Q8WY17

UniProtKB/TrEMBL

A0A0G2JPI4

Related

ENSP00000332284.3, ENST00000329464.9

Conserved Domains (3) summary

cd15818
Location:311 → 497

SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)

cl17238
Location:41 → 81

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:168 → 299

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits