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    ADE16 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ADE16
    Official Full Name
    bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16
    Primary source
    SGD:S000004018
    Locus tag
    YLR028C
    See related
    AllianceGenome:SGD:S000004018; FungiDB:YLR028C; VEuPathDB:YLR028C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ADE16 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (199540..201315, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene aspartate transaminase AAT2 Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L15A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. Tibbetts AS, et al. Arch Biochem Biophys, 1997 Apr 15. PMID 9143321
    2. Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae. Tibbetts AS, et al. J Biol Chem, 2000 Jul 7. PMID 10877846
    3. Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast. Hürlimann HC, et al. J Biol Chem, 2011 Sep 2. PMID 21757731, Free PMC Article
    4. Dysregulation of purine nucleotide biosynthesis pathways modulates cisplatin cytotoxicity in Saccharomyces cerevisiae. Kowalski D, et al. Mol Pharmacol, 2008 Oct. PMID 18612078, Free PMC Article
    5. Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis. Denis V, et al. Mol Microbiol, 1998 Nov. PMID 9822821

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables IMP cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP cyclohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables IMP cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16
    NP_013128.1
    • Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      199540..201315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181915.1 → NP_013128.1  TPA: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY30, E9PAG6, P54113
      UniProtKB/TrEMBL
      A7A0T4, B3LT01, B5VMW6, C7GXH4, G2WIM2
      Conserved Domains (1) summary
      COG0138
      Location:4 → 591
      PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54113.1

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