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    LIP2 lipoyl(octanoyl) transferase LIP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LIP2
    Official Full Name
    lipoyl(octanoyl) transferase LIP2
    Primary source
    SGD:S000004229
    Locus tag
    YLR239C
    See related
    AllianceGenome:SGD:S000004229; FungiDB:YLR239C; VEuPathDB:YLR239C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ligase activity. Involved in protein lipoylation. Located in mitochondrion. Used to study glycine encephalopathy. Orthologous to human LIPT2 (lipoyl(octanoyl) transferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LIP2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (616332..617318, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene thiamine transporter THI7 Neighboring gene Far10p Neighboring gene phosphatidylinositol 3-kinase VPS34 Neighboring gene Csc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The isolation and characterisation of a Saccharomyces cerevisiae gene (LIP2) involved in the attachment of lipoic acid groups to mitochondrial enzymes. Marvin ME, et al. FEMS Microbiol Lett, 2001 May 15. PMID 11356580
    2. The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis. Hermes FA, et al. Yeast, 2013 Oct. PMID 23960015, Free PMC Article
    3. A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione. Mounkoro P, et al. Free Radic Biol Med, 2021 Jan. PMID 33232753
    4. Lipoic acid synthesis and attachment in yeast mitochondria. Schonauer MS, et al. J Biol Chem, 2009 Aug 28. PMID 19570983, Free PMC Article
    5. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. Habarou F, et al. Am J Hum Genet, 2017 Aug 3. PMID 28757203, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lipoyl(octanoyl) transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipoyl(octanoyl) transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein lipoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipoyl(octanoyl) transferase LIP2
    NP_013340.1
    • Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      616332..617318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182126.1 → NP_013340.1  TPA: lipoyl(octanoyl) transferase LIP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013340.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYN7, Q06005
      UniProtKB/TrEMBL
      A7A1C2, B3RHC4, C7GQZ7, G2WJ65, N1NYF9
      Conserved Domains (1) summary
      cl14057
      Location:90 → 309
      BPL_LplA_LipB; biotin-lipoate ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06005.1

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