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    RKM3 protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RKM3
    Official Full Name
    protein-lysine N-methyltransferase
    Primary source
    SGD:S000000234
    Locus tag
    YBR030W
    See related
    AllianceGenome:SGD:S000000234; FungiDB:YBR030W; VEuPathDB:YBR030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine monomethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RKM3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (298292..299950)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative protein kinase YPK3 Neighboring gene phosphatidate cytidylyltransferase Neighboring gene ribosomal 60S subunit protein L4A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction of CDP-diacylglycerol synthase activity results in the excretion of inositol by Saccharomyces cerevisiae. Shen H, et al. J Biol Chem, 1996 Nov 15. PMID 8910557
    2. A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10. Porras-Yakushi TR, et al. J Biol Chem, 2006 Nov 24. PMID 17005568
    3. Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab. Webb KJ, et al. J Biol Chem, 2008 Dec 19. PMID 18957409, Free PMC Article
    4. Stoichiometry of Saccharomyces cerevisiae lysine methylation: insights into non-histone protein lysine methyltransferase activity. Hart-Smith G, et al. J Proteome Res, 2014 Mar 7. PMID 24517342
    5. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine monomethylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-lysine monomethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-lysine N-methyltransferase
    NP_009586.1
    • Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      298292..299950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178378.1 → NP_009586.1  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009586.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ31, P38222
      UniProtKB/TrEMBL
      C7GM23
      Conserved Domains (1) summary
      cd10527
      Location:27 → 349
      SET_LSMT; SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38222.1

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