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    BIRC5 baculoviral IAP repeat containing 5 [ Homo sapiens (human) ]

    Gene ID: 332, updated on 10-Dec-2024

    Summary

    Official Symbol
    BIRC5provided by HGNC
    Official Full Name
    baculoviral IAP repeat containing 5provided by HGNC
    Primary source
    HGNC:HGNC:593
    See related
    Ensembl:ENSG00000089685 MIM:603352; AllianceGenome:HGNC:593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    API4; EPR-1
    Summary
    This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Biased expression in bone marrow (RPKM 13.2), testis (RPKM 10.8) and 12 other tissues See more
    Orthologs
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    Genomic context

    See BIRC5 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78214253..78225635)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79108345..79119727)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76210334..76221716)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76171843-76172621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76172622-76173399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76180346-76181247 Neighboring gene thymidine kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9052 Neighboring gene arylformamidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12879 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:76207979-76208182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76210079-76210980 Neighboring gene MPRA-validated peak3015 silencer Neighboring gene transmembrane protein 235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12882 Neighboring gene MPRA-validated peak3016 silencer Neighboring gene uncharacterized LOC105371910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76246144-76246789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12883 Neighboring gene threonine aldolase 1, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (841 hits/1274 screens)

    EBI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    EBI GWAS Catalog
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates survivin expression by transactivating the survivin promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cobalt ion binding PubMed 
    enables cysteine-type endopeptidase inhibitor activity  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process PubMed 
    enables enzyme binding PubMed 
    enables identical protein binding PubMed 
    enables metal ion binding  
    enables microtubule binding PubMed 
    enables microtubule binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein-folding chaperone binding PubMed 
    enables small GTPase binding PubMed 
    enables tubulin binding PubMed 
    enables zinc ion binding PubMed 
    enables zinc ion binding PubMed 
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle PubMed 
    involved_in apoptotic process  
    involved_in cell division PubMed 
    involved_in chromosome segregation  
    involved_in establishment of chromosome localization PubMed 
    involved_in mitotic cell cycle PubMed 
    involved_in mitotic cell cycle PubMed 
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis PubMed 
    involved_in mitotic cytokinesis PubMed 
    involved_in mitotic spindle assembly PubMed 
    involved_in mitotic spindle assembly checkpoint signaling PubMed 
    involved_in mitotic spindle midzone assembly PubMed 
    involved_in mitotic spindle organization  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity PubMed 
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of exit from mitosis PubMed 
    involved_in positive regulation of mitotic cell cycle PubMed 
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint PubMed 
    involved_in positive regulation of mitotic cytokinesis PubMed 
    involved_in positive regulation of mitotic sister chromatid separation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein-containing complex localization PubMed 
    involved_in sensory perception of sound PubMed 
    Items 1 - 25 of 30
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in centriole PubMed 
    part_of chromosome passenger complex  
    part_of chromosome passenger complex PubMed 
    located_in chromosome, centromeric region PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasmic microtubule PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in interphase microtubule organizing center PubMed 
    is_active_in kinetochore  
    located_in kinetochore PubMed 
    located_in microtubule  
    located_in microtubule cytoskeleton PubMed 
    located_in midbody PubMed 
    located_in nuclear chromosome PubMed 
    located_in nucleoplasm  
    located_in nucleus PubMed 
    part_of protein-containing complex PubMed 
    located_in spindle microtubule PubMed 
    is_active_in spindle midzone  
    part_of survivin complex PubMed 
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 5
    Names
    apoptosis inhibitor 4
    apoptosis inhibitor survivin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029069.1 RefSeqGene

      Range
      5058..16440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012270.2 → NP_001012270.1  baculoviral IAP repeat-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001012270.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as survivin-deltaEx3, lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AI800528, AL519719, AL547142, BC008718, BG178974, BI254058, BI520186, BM476145
      Consensus CDS
      CCDS32751.1
      UniProtKB/TrEMBL
      A0A7L8XZM3
      Related
      ENSP00000364086.1, ENST00000374948.6
      Conserved Domains (1) summary
      pfam00653
      Location:18 → 76
      BIR; Inhibitor of Apoptosis domain
    2. NM_001012271.2 → NP_001012271.1  baculoviral IAP repeat-containing protein 5 isoform 3

      See identical proteins and their annotated locations for NP_001012271.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as survivin-2B, includes an alternate in-frame segment, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct sequence when it is compared to isoform 1.
      Source sequence(s)
      AB028869, AI800528, AL519719, BC008718, BE537971, BG759111, BI254058, BI520186, BQ687404, CB112371
      Consensus CDS
      CCDS32752.1
      UniProtKB/TrEMBL
      H3BLT4
      Related
      ENSP00000301633.3, ENST00000301633.8
      Conserved Domains (1) summary
      pfam00653
      Location:18 → 110
      BIR; Inhibitor of Apoptosis domain
    3. NM_001168.3 → NP_001159.2  baculoviral IAP repeat-containing protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001159.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the most frequently occurring transcript and it encodes isoform 1.
      Source sequence(s)
      AI800528, AL519719, BC008718, BC034148, BG759111, BI254058, BI520186
      Consensus CDS
      CCDS11755.1
      UniProtKB/TrEMBL
      A0A0B4J1S3
      Related
      ENSP00000324180.4, ENST00000350051.8
      Conserved Domains (1) summary
      pfam00653
      Location:18 → 87
      BIR; Inhibitor of Apoptosis domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78214253..78225635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79108345..79119727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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