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    TACR3 tachykinin receptor 3 [ Homo sapiens (human) ]

    Gene ID: 6870, updated on 10-Dec-2024

    Summary

    Official Symbol
    TACR3provided by HGNC
    Official Full Name
    tachykinin receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:11528
    See related
    Ensembl:ENSG00000169836 MIM:162332; AllianceGenome:HGNC:11528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NK3; NKR; HH11; NK3R; NK-3R; TAC3R; TAC3RL
    Summary
    This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TACR3 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (103586031..103719985, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (106897954..107031922, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (104507188..104641142, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr4:104345927-104346428 Neighboring gene long intergenic non-protein coding RNA 2428 Neighboring gene TACR3 antisense RNA 1 Neighboring gene DEAD-box helicase 3 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:104867518-104868402 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:104868403-104869285 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:104869315-104869938 Neighboring gene RNA, U6 small nuclear 635, pseudogene Neighboring gene long intergenic non-protein coding RNA 2503

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC148060, MGC148061

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tachykinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tachykinin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuromedin-K receptor
    Names
    NK-3 receptor
    NK3 receptor
    neurokinin B receptor
    neurokinin beta receptor
    NP_001050.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023344.1 RefSeqGene

      Range
      5001..135349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001059.3NP_001050.1  neuromedin-K receptor

      See identical proteins and their annotated locations for NP_001050.1

      Status: REVIEWED

      Source sequence(s)
      AC004065, AC105460, M89473
      Consensus CDS
      CCDS3664.1
      UniProtKB/Swiss-Prot
      P29371, Q0P510
      UniProtKB/TrEMBL
      A0A1B0RPQ1
      Related
      ENSP00000303325.2, ENST00000304883.3
      Conserved Domains (1) summary
      cd16003
      Location:86367
      7tmA_NKR_NK3R; neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      103586031..103719985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      106897954..107031922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)