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    VPS3 CORVET complex subunit VPS3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS3
    Official Full Name
    CORVET complex subunit VPS3
    Primary source
    SGD:S000002903
    Locus tag
    YDR495C
    See related
    AllianceGenome:SGD:S000002903; FungiDB:YDR495C; VEuPathDB:YDR495C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PEP6; VPL3; VPT17
    Summary
    Involved in protein targeting to vacuole; vacuolar acidification; and vacuole inheritance. Located in endosome. Part of CORVET complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1438115..1441150, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mzm1p Neighboring gene mitochondrial 37S ribosomal protein RSM28 Neighboring gene Puf6p Neighboring gene myo-inositol transporter ITR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle. Raymond CK, et al. J Cell Biol, 1990 Sep. PMID 2202738, Free PMC Article
    2. Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins. Rothman JH, et al. J Cell Biol, 1989 Jul. PMID 2526133, Free PMC Article
    3. Overexpression of genes involved in vesicular trafficking to the vacuole defends against lethal effects of oxidative damage. Martinez M, et al. Cell Mol Biol (Noisy-le-grand), 2003 Nov. PMID 14682384
    4. Components of Golgi-to-vacuole trafficking are required for nitrogen- and TORC1-responsive regulation of the yeast GATA factors. Fayyadkazan M, et al. Microbiologyopen, 2014 Jun. PMID 24644271, Free PMC Article
    5. The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments. Markgraf DF, et al. Mol Biol Cell, 2009 Dec. PMID 19828734, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole.
      Title: Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole.
    2. C-terminal alpha-helical segments of VPS3 and VPS8 are necessary for CORVET assembly and function.
      Title: The N-terminal domains of Vps3 and Vps8 are critical for localization and function of the CORVET tethering complex on endosomes.
    3. Vps3 has an epistatic relationship with Pdr5, a major yeast multidrug transporter.
      Title: Pdr5-mediated multidrug resistance requires the CPY-vacuolar sorting protein Vps3: are xenobiotic compounds routed from the vacuole to plasma membrane transporters for efflux?
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CORVET complex subunit VPS3
    NP_010783.3
    • Component of CORVET membrane tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1438115..1441150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180803.3 → NP_010783.3  TPA: CORVET complex subunit VPS3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010783.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTB7, P23643
      UniProtKB/TrEMBL
      A6ZZ84
      Conserved Domains (1) summary
      COG5271
      Location:11 → 120
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23643.1

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