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    TVP38 Tvp38p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TVP38
    Official Full Name
    Tvp38p
    Primary source
    SGD:S000001796
    Locus tag
    YKR088C
    See related
    AllianceGenome:SGD:S000001796; FungiDB:YKR088C; VEuPathDB:YKR088C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitotic spindle elongation and vesicle-mediated transport. Located in Golgi membrane. Orthologous to human TMEM64 (transmembrane protein 64). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TVP38 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (604405..605418, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene DEAH-box RNA helicase PRP16 Neighboring gene metalloendopeptidase Neighboring gene triacylglycerol lipase Neighboring gene Pxl1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1. Kihara A, et al. Mol Cell Biol, 2005 Nov. PMID 16227572, Free PMC Article
    2. Deletion of 24 open reading frames from chromosome XI from Saccharomyces cerevisiae and phenotypic analysis of the deletants. Zúñiga S, et al. Gene, 1999 Jun 11. PMID 10375630
    3. The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat. Shortill SP, et al. Elife, 2022 Aug 8. PMID 35938928, Free PMC Article
    4. ER exit sites are physical and functional core autophagosome biogenesis components. Graef M, et al. Mol Biol Cell, 2013 Sep. PMID 23904270, Free PMC Article
    5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tvp proteins collectively assist in the effective maintenance/function of the late Golgi/endosomal compartments.
      Title: Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tvp38p
    NP_013014.3
    • Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      604405..605418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179878.3 → NP_013014.3  TPA: Tvp38p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013014.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A047, D6VXE8, P36164
      UniProtKB/TrEMBL
      B3LRG2, B5VMN0, C7GXC2, C8ZCP9, G2WIB5
      Conserved Domains (2) summary
      COG0398
      Location:83 → 322
      TVP38; Uncharacterized membrane protein YdjX, TVP38/TMEM64 family, SNARE-associated domain [Function unknown]
      pfam19146
      Location:27 → 59
      DUF5828; Family of unknown function (DUF5828)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36164.1

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