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    ZIP2 Zip2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZIP2
    Official Full Name
    Zip2p
    Primary source
    SGD:S000003218
    Locus tag
    YGL249W
    See related
    AllianceGenome:SGD:S000003218; FungiDB:YGL249W; VEuPathDB:YGL249W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA secondary structure binding activity. Involved in positive regulation of protein sumoylation; reciprocal meiotic recombination; and synaptonemal complex assembly. Located in synaptonemal complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZIP2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (33098..35212)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene DNA helicase Neighboring gene Rmr1p Neighboring gene ncRNA Neighboring gene 3',5'-cyclic-nucleotide phosphodiesterase PDE1 Neighboring gene Brr6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Chua PR, et al. Cell, 1998 May 1. PMID 9590170
    2. Initiation of meiotic chromosome synapsis at centromeres in budding yeast. Tsubouchi T, et al. Genes Dev, 2008 Nov 15. PMID 19056898, Free PMC Article
    3. Global analysis of the meiotic crossover landscape. Chen SY, et al. Dev Cell, 2008 Sep. PMID 18691940, Free PMC Article
    4. The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2. Tsubouchi T, et al. Dev Cell, 2006 Jun. PMID 16740482
    5. The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Novak JE, et al. Genetics, 2001 Jul. PMID 11454751, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ur data support a model in which the Zip2:Zip4:Spo16 complex binds and stabilizes early meiotic recombination intermediates, then coordinates additional factors to promote crossover formation and license downstream events including synaptonemal complex assembly.
      Title: The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding.
    2. Identification of the ZZS (Zip2-Zip4-Spo16) complex which is required for crossover formation.
      Title: A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.
    3. Spo22 (also called Zip4) is identified as a probable functional collaborator of Zip2/3
      Title: Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA secondary structure binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zip2p
    NP_011265.1
    • Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      33098..35212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181115.1 → NP_011265.1  TPA: Zip2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV86, P53061
      UniProtKB/TrEMBL
      B3LHU1, C8Z809
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53061.1

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