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    LDB17 Ldb17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LDB17
    Official Full Name
    Ldb17p
    Primary source
    SGD:S000002305
    Locus tag
    YDL146W
    See related
    AllianceGenome:SGD:S000002305; FungiDB:YDL146W; VEuPathDB:YDL146W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable Arp2/3 complex binding activity. Involved in endocytosis. Located in actin cortical patch. Orthologous to human NCKIPSD (NCK interacting protein with SH3 domain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LDB17 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (192750..194225)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene snoRNA-binding rRNA-processing protein NOP14 Neighboring gene proteasome regulatory particle lid subunit RPN5 Neighboring gene coatomer subunit alpha Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulators of yeast endocytosis identified by systematic quantitative analysis. Burston HE, et al. J Cell Biol, 2009 Jun 15. PMID 19506040, Free PMC Article
    2. The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p. Shen D, et al. J Cell Biol, 2013 Aug 5. PMID 23897890, Free PMC Article
    3. The fungicidal activity of amphotericin B requires autophagy-dependent targeting to the vacuole under a nutrient-starved condition in Saccharomyces cerevisiae. Yoshioka M, et al. Microbiology (Reading), 2016 May. PMID 26940206
    4. Identification of aluminium transport-related genes via genome-wide phenotypic screening of Saccharomyces cerevisiae. Tun NM, et al. Metallomics, 2014 Aug. PMID 24926745
    5. A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Tong AH, et al. Science, 2002 Jan 11. PMID 11743162

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud HDA PubMed 
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ldb17p
    NP_010135.1
    • Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      192750..194225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180206.1 → NP_010135.1  TPA: Ldb17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRK2, Q12342
      UniProtKB/TrEMBL
      A6ZXI1, N1P7M4
      Conserved Domains (1) summary
      pfam09431
      Location:235 → 372
      DUF2013; Protein of unknown function (DUF2013)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12342.1

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