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    DAD2 Dad2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAD2
    Official Full Name
    Dad2p
    Primary source
    SGD:S000001791
    Locus tag
    YKR083C
    See related
    AllianceGenome:SGD:S000001791; FungiDB:YKR083C; VEuPathDB:YKR083C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSK1
    Summary
    Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DAD2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (596421..596822, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene rRNA-binding ribosome biosynthesis protein RPF2 Neighboring gene Nup133p Neighboring gene ribosome dissociation factor GTPase HBS1 Neighboring gene mitochondrial 54S ribosomal protein YmL20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Implication of a novel multiprotein Dam1p complex in outer kinetochore function. Cheeseman IM, et al. J Cell Biol, 2001 Dec 24. PMID 11756468, Free PMC Article
    2. A method for reverse interactome analysis: High-resolution mapping of interdomain interaction network in Dam1 complex and its specific disorganization based on the interaction domain expression. Ikeuchi A, et al. Biotechnol Prog, 2010 Jul-Aug. PMID 20730753
    3. A simple and inexpensive quantitative technique for determining chemical sensitivity in Saccharomyces cerevisiae. Hung CW, et al. Sci Rep, 2018 Aug 9. PMID 30093662, Free PMC Article
    4. Subunit organization in the Dam1 kinetochore complex and its ring around microtubules. Ramey VH, et al. Mol Biol Cell, 2011 Nov. PMID 21965284, Free PMC Article
    5. A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast. Kiermaier E, et al. Nat Cell Biol, 2009 Sep. PMID 19684577

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dad2p
    NP_013009.1
    • Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      596421..596822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179873.1 → NP_013009.1  TPA: Dad2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013009.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXE3, P36162
      UniProtKB/TrEMBL
      A7A042, G2WIB0
      Conserved Domains (1) summary
      pfam08654
      Location:6 → 129
      DASH_Dad2; DASH complex subunit Dad2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36162.1

    Gene LinkOut

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