TDH2 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TDH2
Official Full Name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2
Primary source: SGD:S000003769
Locus tag: YJR009C
See related: AllianceGenome:SGD:S000003769; FungiDB:YJR009C; VEuPathDB:YJR009C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GLD2
Summary: Enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; melatonin binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including gluconeogenesis; glycolytic process; and reactive oxygen species metabolic process. Located in several cellular components, including fungal-type cell wall; lipid droplet; and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TDH2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (453683..454681, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IDA Inferred from Direct Assay more info	PubMed
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables melatonin binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in external encapsulating structure	IEA Inferred from Electronic Annotation more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2

NP_012542.1

EC 1.2.1.12

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

453683..454681 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181666.1 → NP_012542.1 TPA: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012542.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWI4, P00358

UniProtKB/TrEMBL

A6ZPX6, A6ZUK2, B3LI45, B3LQA8, B5VJD4, C8Z985, C8ZBG4, G2WH19, N1P004

Conserved Domains (1) summary

PLN02272
Location:2 → 330

PLN02272; glyceraldehyde-3-phosphate dehydrogenase