NSE4 Smc5-Smc6 complex subunit NSE4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NSE4
Official Full Name: Smc5-Smc6 complex subunit NSE4
Primary source: SGD:S000002263
Locus tag: YDL105W
See related: AllianceGenome:SGD:S000002263; FungiDB:YDL105W; VEuPathDB:YDL105W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: QRI2
Summary: Contributes to SUMO transferase activity. Involved in DNA repair. Located in nucleus. Part of Smc5-Smc6 complex. Orthologous to several human genes including NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NSE4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (272389..273597)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smc5 and Smc6 associate with each other at their hinge regions and constitute the backbone of the complex, whereas the Nse1-6 subunits form three distinct subcomplexes/entities that interact with different regions of Smc5 and Smc6.
Title: Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.
demonstrated a role for Qri2 in the essential DNA repair function of the Smc5/6 complex; findings could imply a role for Nse4 in maintenance of higher order chromosome structure
Title: Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to SUMO transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Smc5-Smc6 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Smc5-Smc6 complex	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Smc5-Smc6 complex subunit NSE4

NP_010178.1

Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

272389..273597

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180164.1 → NP_010178.1 TPA: Smc5-Smc6 complex subunit NSE4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010178.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRP5, P43124

UniProtKB/TrEMBL

A6ZXM4, B3LGZ6, B5VFG4, C7GJL1, C8Z6J9, N1P7M5

Conserved Domains (1) summary

COG5125
Location:97 → 402

COG5125; Uncharacterized conserved protein [Function unknown]