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    PEX15 Pex15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEX15
    Official Full Name
    Pex15p
    Primary source
    SGD:S000005404
    Locus tag
    YOL044W
    See related
    AllianceGenome:SGD:S000005404; FungiDB:YOL044W; VEuPathDB:YOL044W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAS21
    Summary
    Enables protein-membrane adaptor activity. Involved in protein import into peroxisome matrix, receptor recycling. Located in peroxisomal membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEX15 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (247150..248301)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Lds2p Neighboring gene serine/threonine protein kinase PSK2 Neighboring gene bifunctional N-glycosylase/AP lyase NTG2 Neighboring gene RNA exonuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane. Elgersma Y, et al. EMBO J, 1997 Dec 15. PMID 9405362, Free PMC Article
    2. Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes. Birschmann I, et al. Mol Biol Cell, 2003 Jun. PMID 12808025, Free PMC Article
    3. The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1. Ali BA, et al. J Biol Chem, 2024 Jan. PMID 38036174, Free PMC Article
    4. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae. Elgersma Y, et al. Genetics, 1993 Nov. PMID 7507454, Free PMC Article
    5. A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum. Lam SK, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21098289, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1.
      Title: The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1.
    2. Pex1/Pex6 heterohexameric motor is a protein translocase that unfolds Pex15 in a pore-loop-dependent and ATP-hydrolysis-dependent manner
      Title: The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.
    3. In yeast, PEX26 follows the pathway that also ensures correct targeting of Pex15: PEX26 enters the endoplasmic reticulum (ER) in a GET-dependent and Pex19-independent manner.
      Title: Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins.
    4. Mutants of PEX1, PEX6, and PEX15 accumulate ubiquitinated receptors at the peroxisomal membrane. This accumulation has been suggested to trigger pexophagy in mammalian cells.
      Title: Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix, receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pex15p
    NP_014598.1
    • Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      247150..248301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183298.1 → NP_014598.1  TPA: Pex15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014598.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W222, Q08215
      UniProtKB/TrEMBL
      G2WMI9, N1NVP5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08215.1

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