NUS1 ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NUS1
Official Full Name: ditrans,polycis-polyprenyl diphosphate synthase
Primary source: SGD:S000002352
Locus tag: YDL193W
See related: AllianceGenome:SGD:S000002352; FungiDB:YDL193W; VEuPathDB:YDL193W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to dehydrodolichyl diphosphate synthase activity. Involved in dolichol biosynthetic process and protein glycosylation. Located in endoplasmic reticulum and lipid droplet. Part of dehydrodolichyl diphosphate synthase complex. Used to study congenital disorder of glycosylation. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NUS1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (114672..115799)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of Nus1, the non-catalytic subunit of cis-PT from Saccharomyces cerevisiae in complex with Rer2
Title: Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to dehydrodolichyl diphosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to dehydrodolichyl diphosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydrodolichyl diphosphate synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dolichol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dolichol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of dehydrodolichyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dehydrodolichyl diphosphate synthase complex	IDA Inferred from Direct Assay more info	PubMed
part_of dehydrodolichyl diphosphate synthase complex	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	HDA more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	HDA more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ditrans,polycis-polyprenyl diphosphate synthase

NP_010088.1

EC 2.5.1.87

Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein trafficking; mutations in human homolog NUS1 have been implicated in congenital scoliosis, neurological impairment, refractory epilepsy, hearing deficit, and visual impairment; human cis-prenyltransferase complex complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

114672..115799

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180253.1 → NP_010088.1 TPA: ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010088.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRG0, Q12063

UniProtKB/TrEMBL

A6ZXD9, B3LH75, B5VF83, C7GV55, C8Z6B0, N1P733

Conserved Domains (1) summary

COG0020
Location:176 → 375

UppS; Undecaprenyl pyrophosphate synthase [Lipid transport and metabolism]