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    mucB sigma factor AlgU regulator MucB [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882064, updated on 11-Sep-2024

    Summary

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    Gene symbol
    mucB
    Gene description
    sigma factor AlgU regulator MucB
    Locus tag
    PA0764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (832507..833457)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene RNA polymerase sigma factor AlgU Neighboring gene sigma factor AlgU negative regulator MucA Neighboring gene positive regulator for alginate biosynthesis MucC Neighboring gene serine protease MucD Neighboring gene elongation factor 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Posttranslational control of the algT (algU)-encoded sigma22 for expression of the alginate regulon in Pseudomonas aeruginosa and localization of its antagonist proteins MucA and MucB (AlgN). Mathee K, et al. J Bacteriol, 1997 Jun. PMID 9171421, Free PMC Article
    2. Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa. Li T, et al. Commun Biol, 2020 Aug 3. PMID 32747658, Free PMC Article
    3. Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa. Li S, et al. FEBS J, 2019 Dec. PMID 31297938
    4. Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB. Cezairliyan BO, et al. Mol Microbiol, 2009 Apr. PMID 19298369, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
      Title: Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
    2. The structures reveal the molecular basis for MucA recognition by MucB in the periplasm and AlgU in the cytoplasm, thus providing an important step in understanding the mechanisms that regulate a key signal transduction pathway involved in P. aeruginosa pathogenesis.
      Title: Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa.
    3. Binding of MucB to MucA inhibits MucA cleavage by AlgW.
      Title: Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of polysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sigma factor AlgU regulator MucB
    NP_249455.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      832507..833457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249455.1 sigma factor AlgU regulator MucB [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249455.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3M5D7D3
      Conserved Domains (1) summary
      COG3026
      Location:14 → 314
      RseB; Negative regulator of sigma E activity [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38108.1

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