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    tpbB diguanylate cyclase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881684, updated on 24-Aug-2024

    Summary

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    Gene symbol
    tpbB
    Gene description
    diguanylate cyclase
    Locus tag
    PA1120
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1213195..1214502, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene pseudo Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa. Chen G, et al. Elife, 2021 Sep 9. PMID 34498587, Free PMC Article
    2. Bacterial cyclic diguanylate signaling networks sense temperature. Almblad H, et al. Nat Commun, 2021 Mar 31. PMID 33790266, Free PMC Article
    3. Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus. Chew SC, et al. mBio, 2018 Nov 6. PMID 30401769, Free PMC Article
    4. Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). Ueda A, et al. PLoS Pathog, 2009 Jun. PMID 19543378, Free PMC Article
    5. Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence. Kulasakara H, et al. Proc Natl Acad Sci U S A, 2006 Feb 21. PMID 16477007, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa.
      Title: Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa.
    2. Bacterial cyclic diguanylate signaling networks sense temperature.
      Title: Bacterial cyclic diguanylate signaling networks sense temperature.
    3. Our data suggest that the competitive effect of Psl polysaccharides is not associated with its structural role in cross-linking the matrix and adhering to P. aeruginosa cells but is instead mediated through the activation of the diguanylate cyclase SiaD.
      Title: Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables diguanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diguanylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables diguanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diguanylate cyclase
    NP_249811.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1213195..1214502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249811.1 diguanylate cyclase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249811.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367MCN9
      Conserved Domains (1) summary
      PRK09966
      Location:10 → 410
      PRK09966; diguanylate cyclase DgcN
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I4L5.1

    Gene LinkOut

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    Molecular Biology Databases