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    gbuA guanidinobutyrase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881747, updated on 24-Aug-2024

    Summary

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    Gene symbol
    gbuA
    Gene description
    guanidinobutyrase
    Locus tag
    PA1421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1546271..1547230, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene transporter Neighboring gene hypothetical protein Neighboring gene protein GbuR Neighboring gene biofilm dispersion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The guanidinobutyrase GbuA is essential for the alkylquinolone-regulated pyocyanin production during parasitic growth of Pseudomonas aeruginosa in co-culture with Aeromonas hydrophila. Jagmann N, et al. Environ Microbiol, 2016 Oct. PMID 27322205
    2. The fourth arginine catabolic pathway of Pseudomonas aeruginosa. Jann A, et al. J Gen Microbiol, 1988 Apr. PMID 3141581
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of GbuA leds to a loss of pyocyanin production in co-cultures and to a reduced pyocyanin production in single cultures.
      Title: The guanidinobutyrase GbuA is essential for the alkylquinolone-regulated pyocyanin production during parasitic growth of Pseudomonas aeruginosa in co-culture with Aeromonas hydrophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables guanidinobutyrase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within arginine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanidinobutyrase
    NP_250112.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1546271..1547230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250112.1 guanidinobutyrase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250112.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367M4N2
      Conserved Domains (1) summary
      cd11592
      Location:19 → 310
      Agmatinase_PAH; Agmatinase-like family includes proclavaminic acid amidinohydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I3S3.1

    Gene LinkOut

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    Research Materials